The former province of Selino preserves monuments from the early Christian centuries through Venetian rule and into more recent times. In Sougia, the remains of a three-aisled early Christian basilica lie beneath the present Church of Saint Panteleimon. At the archaeological site of Lissos, the churches of Saint Kerykos and Panagia were built on the sites of earlier basilicas.

In Azogyres, local tradition links the Monastery of the Holy Fathers and the nearby caves to Saint John the Hermit and the 98 ascetics who lived alongside him. Konstantinos Kriaris built the monastery in 1864 at the site where the ascetics are said to have settled.

Kandanos and its surrounding hamlets preserve a remarkable concentration of churches with frescoes. At Kavalariana, the Church of Archangel Michael was painted in 1327–1328. At Trahiniakos, the frescoes in the Church of Saint John the Theologian are associated with the work of Ioannis Pagomenos. Frescoes by the same painter survive in the Church of Saint George at Anydri, where they date to 1323.

In other villages of Selino, the churches themselves reveal successive phases of worship. At Plemeniana, the Church of Christ the Saviour was built on the site of an early Christian church, of which some marble architectural elements survive. At Sarakina, the Church of Archangel Michael stands on the site of the central aisle of an earlier three-aisled basilica.