The church of Saint Isidore (Agios Isidoros) is built on a small plateau atop a hill in the small settlement Tzinaliana in Kakodiki, province Selino. It belongs to the architectural type of the one-room arched-roofed temples. At the entrance we can see two parts of an ancient Doric architrave.
The church is dedicated to Saint Isidore of Pelusium (feast. 4 February) who lived in the 5th century, while it is believed that the temple initially commemorated Saint Isidore of Alexandria who was martyred in Chios in 250AD. In honor of the second, the temple also celebrates on May 15th.
The frescoes are dated to 1420-21, according to an inscription mentioned by Gerola. The frescoes are preserved in very good condition and are the work of a very skilled painter who expresses the academic tendencies of the Paleologean art (from Constantinople). At the front of the east wall we see the Holy Mandylion, in the quadrangle of the sanctuary we see Christ Pantocrator and co-officiating hierarchs. The arch of the sanctuary is dominated by scenes from the Evangelical circle and the scene of the martyrdom of Saint Isidore, while the lower ones depict military saints.