The province of Rethymnon still hosts a large number of monasteries and inactive convents that mostly flourished during the Venetian Era, i.e. before the Fall of Rethymnon in 1646 by the Ottomans. The area around the current city was a very important religious center.
The church of Saint Kyriaki (Agia Kiriaki) is located on the banks of the river Mouselas, fed by the rich springs of Argyroupolis. It is the result of the conversion of a late Roman bath to a church in the 9th century.