The E4 European long-distance trail crosses Crete eastwards from Kissamos. The Cretan section heads south towards Elafonisi, then follows coastal and mountain routes to Kato Zakros. The network continues north along the eastern coast towards Karoumes and Chochlakies.

At Sougia, the E4 splits into two branches. The southern branch follows the coast towards Agia Roumeli, while the northern branch climbs towards Omalos via Koustogerako. In central Crete, the route from Nida to Rouvas Forest leads from the plateau on Psiloritis into wooded slopes. In the east, the Kato Zakros – Pelekita Cave – Karoumes section follows the rocky coast.

The E4 is waymarked in yellow and black. Its sections vary in distance, elevation change and terrain. The map gives an overview of the network, while the individual route descriptions help with choosing a section.