Directly opposite the port of Agios Nikolaos lies the islet of Agii Pantes, which takes its name from the small church dedicated to All Saints. On the feast day of the church, celebrated 56 days after Orthodox Easter, dozens of residents travel to the island by boat to attend the religious service. Next to the church of Agii Pantes stands a vaulted building dating back to the Venetian period.

Scattered across the island are several military structures dating from the Second World War, when the Lassithi region was occupied by Italian forces. Numerous circular gun emplacements can still be seen, along with fortifications at several locations. An old military observation post also survives on the eastern side of the island.

Together with the neighbouring islet of Mikronisi, Agii Pantes acts as a natural breakwater, protecting the harbour of Agios Nikolaos from strong waves. Hybrids of the endangered Cretan ibex, locally known as agrimia, have also been transferred to the island for their protection. Near the centre of the islet, there is a unique tiny sandy beach with clear turquoise water.